Edward V Prochownik Selected Research

10074-G5

1/2014	Targeting of the MYCN protein with small molecule c-MYC inhibitors.
12/2010	In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.

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Edward V Prochownik Research Topics

Disease

37	Neoplasms (Cancer) 04/2022 - 11/2002
6	Carcinogenesis 01/2022 - 06/2003
6	Hepatoblastoma 04/2021 - 12/2016
3	Necrosis 04/2021 - 01/2021
3	Liver Neoplasms (Liver Cancer) 01/2021 - 10/2018
3	Breast Neoplasms (Breast Cancer) 04/2020 - 06/2010
3	Genomic Instability 10/2010 - 09/2008
3	Tetraploidy 04/2010 - 02/2007
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2020
2	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 01/2017
2	Neoplasm Metastasis (Metastasis) 09/2008 - 06/2003
1	Intestinal Neoplasms (Intestinal Cancer) 01/2022
1	Dysbiosis 01/2022
1	Cysts 04/2021
1	Liver Failure 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 06/2015
1	Multiple Myeloma 06/2015
1	Neuroblastoma 01/2014
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2012
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/2011
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 08/2011
1	Burkitt Lymphoma (Burkitt's Lymphoma) 12/2010
1	Chromosomal Instability (Chromosome Stability) 05/2007
1	Aneuploidy (Aneuploid) 05/2007

Drug/Important Bio-Agent (IBA)

15	Oncogene Proteins (Oncogene Protein)IBA 01/2019 - 09/2003
12	Transcription Factors (Transcription Factor)IBA 01/2022 - 12/2005
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2010
5	CateninsIBA 01/2022 - 12/2016
4	Biological ProductsIBA 04/2021 - 11/2002
3	CholesterolIBA 01/2022 - 01/2019
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 01/2019
3	EnzymesIBA 07/2019 - 10/2018
3	LipidsIBA 12/2016 - 01/2014
3	DNA (Deoxyribonucleic Acid)IBA 01/2012 - 09/2008
3	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2010 - 05/2007
2	AntioxidantsIBA 04/2021 - 12/2005
2	Ribosomal Proteins (Ribosomal Protein)IBA 07/2019 - 12/2018
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 06/2003
2	Acetyl Coenzyme A (Acetyl-CoA)IBA 12/2016 - 09/2014
2	MicroRNAs (MicroRNA)IBA 03/2016 - 01/2016
2	Pharmaceutical PreparationsIBA 06/2015 - 06/2009
2	10074-G5IBA 01/2014 - 12/2010
1	Cholesterol Esters (Cholesteryl Esters)IBA 04/2022
1	Sterol O-AcyltransferaseIBA 04/2022
1	Ubiquitin-Specific ProteasesIBA 04/2022
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2022
1	dihydroceramide desaturaseIBA 01/2022
1	avasimibeIBA 01/2022
1	sterol O-acyltransferase 1IBA 01/2022
1	AzoxymethaneIBA 01/2022
1	CeramidesIBA 01/2022
1	Dextrans (Dextran)FDA Link 01/2022
1	Therapeutic UsesIBA 01/2022
1	Peroxisomal Bifunctional EnzymeIBA 01/2021
1	lauric acid (dodecanoic acid)IBA 01/2021
1	dodecanedioic acidIBA 01/2021
1	F-Box ProteinsIBA 01/2021
1	AcidsIBA 01/2021
1	Plasminogen Activator Inhibitor 1IBA 01/2021
1	Hormones (Hormone)IBA 04/2020
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2020
1	NADP (NADPH)IBA 01/2020
1	Pyruvic Acid (Pyruvate)IBA 01/2019
1	Oxidoreductases (Dehydrogenase)IBA 01/2019
1	Deubiquitinating EnzymesIBA 01/2018
1	PlasticsIBA 01/2018
1	Oxygen (Dioxygen)IBA 01/2018
1	Tricarboxylic AcidsIBA 11/2017
1	Amino Acids FDA Link 11/2017
1	TriterpenesIBA 10/2015
1	celastrolIBA 10/2015
1	Adenosine Triphosphate (ATP)IBA 06/2015
1	IntegrinsIBA 06/2015
1	ProdrugsIBA 06/2015
1	Lipase (Acid Lipase)FDA Link 06/2015
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 09/2012
1	Messenger RNA (mRNA)IBA 08/2011
1	afimoxifene (hydroxytamoxifen)IBA 08/2011
1	Green Fluorescent ProteinsIBA 06/2010
1	ChromatinIBA 04/2010
1	Aurora Kinase BIBA 04/2010
1	Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)IBA 04/2010
1	NucleotidesIBA 09/2008
1	Small Interfering RNA (siRNA)IBA 02/2007
1	TransferasesIBA 11/2004
1	Capsules (Microcapsules)IBA 06/2003
1	ChemokinesIBA 06/2003

Therapy/Procedure

5	Therapeutics 01/2016 - 11/2010
1	Drug Therapy (Chemotherapy) 09/2008